Cell Reproduction part 2 Concept Review 2

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Figure 10.13 Rb halts the cell cycle and releases its hold in response to cell growth.

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Figure 10.14 The role of normal p53 is to monitor DNA and the supply of oxygen (hypoxia is a condition of reduced
oxygen supply). If damage is detected, p53 triggers repair mechanisms. If repairs are unsuccessful, p53 signals
apoptosis. A cell with an abnormal p53 protein cannot repair damaged DNA and thus cannot signal apoptosis.
Cells with abnormal p53 can become cancerous. (credit: modification of work by Thierry Soussi)

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16. At which of the cell cycle checkpoints do external
forces have the greatest influence?

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What is the main prerequisite for clearance at the G2
checkpoint?

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If the M checkpoint is not cleared, what stage of
mitosis will be blocked?

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Which protein is a positive regulator that
phosphorylates other proteins when activated?

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Many of the negative regulator proteins of the cell
cycle were discovered in what type of cells?

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___________ are changes to the order of nucleotides
in a segment of DNA that codes for a protein.

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A mutated gene that codes for an altered version of
Cdk that is active in the absence of cyclin is a(n) _____.

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Cell Reproduction part 2 Concept Review 2

16. At which of the cell cycle checkpoints do externalforces have the greatest influence?

What is the main prerequisite for clearance at the G2checkpoint?

If the M checkpoint is not cleared, what stage ofmitosis will be blocked?

Which protein is a positive regulator thatphosphorylates other proteins when activated?

Many of the negative regulator proteins of the cellcycle were discovered in what type of cells?

___________ are changes to the order of nucleotidesin a segment of DNA that codes for a protein.

A mutated gene that codes for an altered version ofCdk that is active in the absence of cyclin is a(n) _____.

16. At which of the cell cycle checkpoints do externalforces have the greatest influence?

What is the main prerequisite for clearance at the G2checkpoint?

If the M checkpoint is not cleared, what stage ofmitosis will be blocked?

Which protein is a positive regulator thatphosphorylates other proteins when activated?

Many of the negative regulator proteins of the cellcycle were discovered in what type of cells?

___________ are changes to the order of nucleotidesin a segment of DNA that codes for a protein.

A mutated gene that codes for an altered version ofCdk that is active in the absence of cyclin is a(n) _____.

16. At which of the cell cycle checkpoints do external
forces have the greatest influence?

What is the main prerequisite for clearance at the G2
checkpoint?

If the M checkpoint is not cleared, what stage of
mitosis will be blocked?

Which protein is a positive regulator that
phosphorylates other proteins when activated?

Many of the negative regulator proteins of the cell
cycle were discovered in what type of cells?

___________ are changes to the order of nucleotides
in a segment of DNA that codes for a protein.

A mutated gene that codes for an altered version of
Cdk that is active in the absence of cyclin is a(n) _____.

16. At which of the cell cycle checkpoints do external
forces have the greatest influence?

What is the main prerequisite for clearance at the G2
checkpoint?

If the M checkpoint is not cleared, what stage of
mitosis will be blocked?

Which protein is a positive regulator that
phosphorylates other proteins when activated?

Many of the negative regulator proteins of the cell
cycle were discovered in what type of cells?

___________ are changes to the order of nucleotides
in a segment of DNA that codes for a protein.

A mutated gene that codes for an altered version of
Cdk that is active in the absence of cyclin is a(n) _____.