Cell Reproduction part 2 Concept Review 2

Last updated almost 8 years ago

13 questions

Note from the author:

1

A review assignment looking at Mitosis   controlee mechanisms

Figure 10.13 Rb halts the cell cycle and releases its hold in response to cell growth.

Figure 10.14 The role of normal p53 is to monitor DNA and the supply of oxygen (hypoxia is a condition of reduced
oxygen supply). If damage is detected, p53 triggers repair mechanisms. If repairs are unsuccessful, p53 signals
apoptosis. A cell with an abnormal p53 protein cannot repair damaged DNA and thus cannot signal apoptosis.
Cells with abnormal p53 can become cancerous. (credit: modification of work by Thierry Soussi)

16. At which of the cell cycle checkpoints do external
forces have the greatest influence?

a. G1 checkpoint

b. G2 checkpoint

c. M checkpoint

d. G0 checkpoint

What is the main prerequisite for clearance at the G2
checkpoint?

a. cell has reached a sufficient size

b. an adequate stockpile of nucleotides

c. accurate and complete DNA replication

d. proper attachment of mitotic spindle fibers to
kinetochores

If the M checkpoint is not cleared, what stage of
mitosis will be blocked?

a. prophase

b. prometaphase

c. metaphase

d. anaphase

Which protein is a positive regulator that
phosphorylates other proteins when activated?

a. p53

b. retinoblastoma protein (Rb)

c. cyclin

d. cyclin-dependent kinase (Cdk)

Many of the negative regulator proteins of the cell
cycle were discovered in what type of cells?

a. gametes

b. cells in G0

c. cancer cells

d. stem cells

___________ are changes to the order of nucleotides
in a segment of DNA that codes for a protein.

a. Proto-oncogenes

b. Tumor suppressor genes

c. Gene mutations

d. Negative regulators

A mutated gene that codes for an altered version of
Cdk that is active in the absence of cyclin is a(n) _____.

a. kinase inhibitor.

b. tumor suppressor gene.

c. proto-oncogene.

d. oncogene.

16. At which of the cell cycle checkpoints do external
forces have the greatest influence?

a. G1 checkpoint

b. G2 checkpoint

c. M checkpoint

d. G0 checkpoint

What is the main prerequisite for clearance at the G2
checkpoint?

a. cell has reached a sufficient size

b. an adequate stockpile of nucleotides

c. accurate and complete DNA replication

d. proper attachment of mitotic spindle fibers to
kinetochores

If the M checkpoint is not cleared, what stage of
mitosis will be blocked?

a. prophase

b. prometaphase

c. metaphase

d. anaphase

Which protein is a positive regulator that
phosphorylates other proteins when activated?

a. p53

b. retinoblastoma protein (Rb)

c. cyclin

d. cyclin-dependent kinase (Cdk)

Many of the negative regulator proteins of the cell
cycle were discovered in what type of cells?

a. gametes

b. cells in G0

c. cancer cells

d. stem cells

___________ are changes to the order of nucleotides
in a segment of DNA that codes for a protein.

a. Proto-oncogenes

b. Tumor suppressor genes

c. Gene mutations

d. Negative regulators

A mutated gene that codes for an altered version of
Cdk that is active in the absence of cyclin is a(n) _____.

a. kinase inhibitor.

b. tumor suppressor gene.

c. proto-oncogene.

d. oncogene.

Cell Reproduction part 2 Concept Review 2

Cell Reproduction part 2 Concept Review 2

16. At which of the cell cycle checkpoints do externalforces have the greatest influence?

What is the main prerequisite for clearance at the G2checkpoint?

If the M checkpoint is not cleared, what stage ofmitosis will be blocked?

Which protein is a positive regulator thatphosphorylates other proteins when activated?

Many of the negative regulator proteins of the cellcycle were discovered in what type of cells?

___________ are changes to the order of nucleotidesin a segment of DNA that codes for a protein.

A mutated gene that codes for an altered version ofCdk that is active in the absence of cyclin is a(n) _____.

16. At which of the cell cycle checkpoints do external
forces have the greatest influence?

What is the main prerequisite for clearance at the G2
checkpoint?

If the M checkpoint is not cleared, what stage of
mitosis will be blocked?

Which protein is a positive regulator that
phosphorylates other proteins when activated?

Many of the negative regulator proteins of the cell
cycle were discovered in what type of cells?

___________ are changes to the order of nucleotides
in a segment of DNA that codes for a protein.

A mutated gene that codes for an altered version of
Cdk that is active in the absence of cyclin is a(n) _____.