Sickle Cell Anemia - Laura Schultz | Biblioteka

Watch the short film The Making of the Fittest: Natural Selection in Humans. While watching pay close attention the the genetics of sickle cell trait and the connection to malaria infection.

1

Individuals with what genotype are most likely to survive in an area in which malaria is prevalent?

SS

AS

AA

An individual who has sickle cell trait has children with an individual who does not have the HbS allele.

1

What are the genotypes of the parents?

AA x AS

AS x AS

AA x AA

AA x SS

1

Complete a Punnett square for this cross

1

What are the chances that one of the couple's children will have sickle cell disease?

100%

50%

25%

0%

1

If this couple lived in an area where malaria is found, what are the chances that one of their children would be resistant to malaria?

100%

50%

25%

0%

1

What is the probability that they will have 3 children all of whom have normal hemoglobin? Show your work.

Use the pedigree to answer the following questions. Black boxes represent individuals with sickle cell anemia

null

1

What is the genotype of individual 1?

AA

AS

SS

Could be AA or AS

1

Explain how you knew the anwer to question 7

1

What is the genotype of individual 6?

AA

AS

SS

Could be AA or AS

1

What is the genotype of individual 18?

AA

AS

SS

Could be AA or AS

1

Which individual on the pedigree are you sure does not carry the sickle cell trait

14

17

12

none of them

1

In 3-5 sentences, explain why sickle cell disease became more prevalent in certain East African populations. Discuss the role of both the genes and the environment.