Everyone has two copies of the BRCA2 gene, one copy inherited from each parent. Even if a person inherits a BRCA2 mutation from one parent, they still have the normal copy of the BRCA2 gene from the other parent.
Cancer occurs when a second mutation happens that affects the normal copy of the gene, so the person no longer has a BRCA2 gene that works properly.
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Question 4
4.
State one notice about Figure 1.
YOU MUST USE NUMBERS FROM THE GRAPH
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Figure 2 shows the risk of breast cancer for BRCA2 patients who have different number of full term pregnancies before the age of 30
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Question 12
12.
What is a mutation and how can a mutation lead to cancer?
Question 13
13.
Describe how mutated genes are passed through a family. Consider meiosis in your answer.
Question 14
14.
BRCA genes prevent cancer tumors from forming.
True
False
Question 2
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Question 3
3.
Cancer occurs when a person has __________ copy of the BRCA2 gene that works properly.
Question 5
5.
By what percentage does the BRCA mutation increase the risk for developing breast cancer and/or ovarian cancer for increased female breast cancer risk by age 50?
Question 6
6.
By what percentage does the BRCA mutation increase the risk for developing breast cancer and/or ovarian cancer for increased female breast cancer risk by age 70?
Question 7
7.
By what percentage does the BRCA mutation increase the risk for developing breast cancer and/or ovarian cancer for increased female 2nd breast cancer risk by age 70?
Question 8
8.
By what percentage does the BRCA mutation increase the risk for developing breast cancer and/or ovarian cancer for male breast cancer by age 70?
Question 9
9.
According to the graph, how does the number of full-term pregnancies before the age of 30 affect a BRCA2 patient's breast cancer risk?
Make a claim and provide 2 pieces of evidence from the graph.
Question 10
10.
Beyonce has 3 children and her sister Solange has 1 child. According to the figure, Beyonce's risk for developing breast cancer is __________ than her sister's chance.
Question 11
11.
Why is it useful for patients who test positive for BRCA2 mutations to also see a genetic counselor and not just use the test results to make decisions? (In other words, why is knowing your genetic information not enough?
Even if someone has inherited the mutation, risk of cancer is affected by many variables beyond genes
Genetic information is not enough because test results can be wrong
Family history may be incorrectly reported
Genetic counselors are the only ones who know how to read the test results.
How many copies of the BRAC2 gene do people have?
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What age range does the risk of breast cancer increase the most when multiple family members have breast cancer?
