Everyone has two copies of the BRCA2 gene, one copy inherited from each parent. Even if a person inherits a BRCA2 mutation from one parent, they still have the normal copy of the BRCA2 gene from the other parent.
Cancer occurs when a second mutation happens that affects the normal copy of the gene, so the person no longer has a BRCA2 gene that works properly.
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Question 3
3.
Cancer occurs when a person has __________ copy of the BRCA2 gene that works properly.
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Question 4
4.
State one notice about Figure 1.
YOU MUST USE NUMBERS FROM THE GRAPH
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Question 5
5.
By what percentage does the BRCA mutation increase the risk for developing breast cancer and/or ovarian cancer for increased female breast cancer risk by age 50?
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Question 6
6.
By what percentage does the BRCA mutation increase the risk for developing breast cancer and/or ovarian cancer for increased female breast cancer risk by age 70?
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Figure 2 shows the risk of breast cancer for BRCA2 patients who have different number of full term pregnancies before the age of 30
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Question 9
9.
According to the graph, how does the number of full-term pregnancies before the age of 30 affect a BRCA2 patient's breast cancer risk?
Make a claim and provide 2 pieces of evidence from the graph.
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Question 10
10.
Beyonce has 3 children and her sister Solange has 1 child. According to the figure, Beyonce's risk for developing breast cancer is __________ than her sister's chance.
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Question 11
11.
What age range does the risk of breast cancer increase the most when multiple family members have breast cancer?
Question 12
12.
What is a mutation and how can a mutation lead to cancer?
Question 13
13.
Describe how mutated genes are passed through a family. Consider meiosis in your answer.
Question 14
14.
Why is it useful for patients who test positive for BRCA2 mutations to also see a genetic counselor and not just use the test results to make decisions? (In other words, why is knowing your genetic information not enough?
Question 2
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How many copies of the BRAC2 gene do people have?
Question 7
7.
By what percentage does the BRCA mutation increase the risk for developing breast cancer and/or ovarian cancer for increased female 2nd breast cancer risk by age 70?
Question 8
8.
By what percentage does the BRCA mutation increase the risk for developing breast cancer and/or ovarian cancer for male breast cancer by age 70?
