Unit 4 Test: Mendelian Genetics

10

Drag 1 black mouse and 1 white mouse into the parent squares. What is the phenotype of all of the offspring?

10

Click on the box that says "Show Genotype". What is the genotype of the offspring?

10

Complete the Punnett Square.
If we were to cross a heterozygous mouse with a homozygous recessive mouse, what would the probability of offspring genotypes be?
fill in the PERCENTAGE of the probability for each genotype in the show your work section.

20

What would the genotype of the parent mice need to be to produce offspring with the chance to have all possible genotpes: FF, Ff, and ff?
(an empty punnett square is provided to show your work)

Sickle Cell Anemia Case Study:
Hemoglobin is a protein found in red blood cells (RBCs) that transports oxygen throughout the body. The hemoglobin protein consists of four polypeptide chains: two alpha chains and two beta chains. Sickle cell disease (also called sickle cell anemia) is caused by a genetic mutation in the DNA sequence that codes for the beta chain of the hemoglobin protein. The mutation causes an amino acid substitution, replacing glutamic acid with valine. Due to this change in amino acid sequence, the hemoglobin tends to precipitate (or clump together) within the RBC after releasing its oxygen. This clumping causes the RBC to assume an abnormal “sickled” shape.

Individuals who are homozygous for the normal hemoglobin allele (HBA) receive a normal hemoglobin allele from each parent and are designated AA genotype. People who are homozygous for normal hemoglobin do not have any sickled RBCs.

Individuals who receive one normal hemoglobin allele from one parent and one mutant hemoglobin, or sickle cell allele (HBS), from the other parent are heterozygous and are said to have sickle cell trait. Their genotype is AS. Heterozygous individuals produce both normal and mutant hemoglobin proteins. These individuals do not have sickle cell disease, and most of their RBCs are normal. However, due to having one copy of the sickle cell allele, these individuals do manifest some sickling of their RBCs in low-oxygen environments.

People with sickle cell disease are homozygous for the sickle cell allele (SS genotype); they have received one copy of the mutant hemoglobin allele from each parent. The resulting abnormal, sickle-shaped RBCs in these people block blood flow in blood vessels, causing pain, serious infections, and organ damage.
Genotype Key:
Normal = AA (Homozygous dominant)
Mostly Normal (Sickle Cell Trait) = AS (Heterozygous)
Sickle Cell Disease = SS (Homozygous recessive)

10

Two individuals who carry the sickle cell trait, but do not have sickle cell anemia are pregnant with a child. What is the probability that the resulting child will inherit sickle cell anemia?
calculate the probability. The punnett square is provided to show your work.

10

Using the punnett square that you created in question number 5, what is the probability that the resulting child would be a carrier (heterozygous) for the sickle cell anemia trait, but not have sickle cell anemia?

10

Using the punnett square that you created in question number 5, what is the probability that the resulting child would have a phenotype of normal hemoglobin?

10

What would the genotype of the parents need to be to produce a child that has a 50% chance of being born homozygous normal and 50% chance of being born heterozygous for the sickle cell anemia trait.
(an empty punnett square is provided to show your work)

10

Two fully heterozygous plants are crossed. Complete the Punnett Square and provide the probabilities for the genotype and phenotype for the offspring.
R is round
r is wrinkled
Y is yellow
y is green
Please provide the probability in percentages
Fill in the blanks using the "Show Your Work" tools

Drag 1 black mouse and 1 white mouse into the parent squares. What is the phenotype of all of the offspring?

Click on the box that says "Show Genotype". What is the genotype of the offspring?

Complete the Punnett Square. If we were to cross a heterozygous mouse with a homozygous recessive mouse, what would the probability of offspring genotypes be? fill in the PERCENTAGE of the probability for each genotype in the show your work section.

What would the genotype of the parent mice need to be to produce offspring with the chance to have all possible genotpes: FF, Ff, and ff? (an empty punnett square is provided to show your work)

Two individuals who carry the sickle cell trait, but do not have sickle cell anemia are pregnant with a child. What is the probability that the resulting child will inherit sickle cell anemia? calculate the probability. The punnett square is provided to show your work.

Using the punnett square that you created in question number 5, what is the probability that the resulting child would be a carrier (heterozygous) for the sickle cell anemia trait, but not have sickle cell anemia?

Using the punnett square that you created in question number 5, what is the probability that the resulting child would have a phenotype of normal hemoglobin?

What would the genotype of the parents need to be to produce a child that has a 50% chance of being born homozygous normal and 50% chance of being born heterozygous for the sickle cell anemia trait. (an empty punnett square is provided to show your work)

Two fully heterozygous plants are crossed. Complete the Punnett Square and provide the probabilities for the genotype and phenotype for the offspring.R is roundr is wrinkledY is yellowy is greenPlease provide the probability in percentagesFill in the blanks using the "Show Your Work" tools

Complete the Punnett Square.
If we were to cross a heterozygous mouse with a homozygous recessive mouse, what would the probability of offspring genotypes be?
fill in the PERCENTAGE of the probability for each genotype in the show your work section.

What would the genotype of the parent mice need to be to produce offspring with the chance to have all possible genotpes: FF, Ff, and ff?
(an empty punnett square is provided to show your work)

Two individuals who carry the sickle cell trait, but do not have sickle cell anemia are pregnant with a child. What is the probability that the resulting child will inherit sickle cell anemia?
calculate the probability. The punnett square is provided to show your work.

What would the genotype of the parents need to be to produce a child that has a 50% chance of being born homozygous normal and 50% chance of being born heterozygous for the sickle cell anemia trait.
(an empty punnett square is provided to show your work)

Two fully heterozygous plants are crossed. Complete the Punnett Square and provide the probabilities for the genotype and phenotype for the offspring.
R is round
r is wrinkled
Y is yellow
y is green
Please provide the probability in percentages
Fill in the blanks using the "Show Your Work" tools