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Unit 5 Test: Molecular Genetics

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Section 1: DNA & RNA

Question 1
1.

Question 2
2.

Question 3
3.

Question 4
4.

Question 5
5.

Question 6
6.

Section 2: SARS-CoV-2

Watch the first video below, Infection, which shows how SARS-CoV-2 infects and replicates inside human cells.
Text
01:04
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Get ready to answer Question 13 now
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Question 10
10.

Watch the second video below, Evolution, which shows how SARS-CoV-2 and other viruses may change over time due to mutations.
Question 11
11.

Watch the third video below, Detection, which shows several ways to test whether someone has been infected by the SARS-CoV-2 virus.
Watch the fourth and final animation, Vaccination, which shows how different types of vaccinations for SARS-CoV-2 prevent disease.
Question 12
12.

Question 13
13.

Question 14
14.

Provide Evidence:
Use evidence, from the videos and prior classwork, to justify the claim you made in the above question.

Question 15
15.

Claim and Evidence:
What would happen to the effectiveness of an original vaccination if a mutation in the virus caused the protein spike to change?
Make a claim that answers the question, then support that claim with evidence. What did you learn about mutations that would support your claim?

The process of creating an mRNA strand from one side of DNA is called:
Protein Synthesis
DNA Replication
Transcription
Translation
Using the strand of mRNA below along with either of the codon charts, place the amino acids in the correct order.


Stop
Lys
Ser
Tyr
Met
Glu
Asn
Arg
Phe
Thr
What is the function of tRNA in protein synthesis?
To combine with other proteins to form the ribosome where protein synthesis takes place
To transfer the amino acids from the cytoplasm to the ribosome where protein synthesis takes place
To match up codons with rRNA to signal the start of protein synthesis
Suppose a mutation occurs in a portion of DNA and this alters the resulting mRNA that is transcribed. Examine the original and mutated mRNA sequences below and describe how the mutation impacts the resulting protein using either of the codon charts. You may check your work here.

mRNA from original DNA:


mRNA from mutated DNA:



It will cause the protein synthesis to stop early
It will cause the resulting amino acid to change
No amino acid change (silent mutation)
Suppose a mutation occurs in a portion of DNA and this alters the resulting mRNA that is transcribed. Examine the original and mutated mRNA sequences below and describe how the mutation impacts the resulting protein using either of the codon charts. You may check your work here.

mRNA from original DNA:


mRNA from mutated DNA:




It will cause the protein synthesis to stop early
It will cause the resulting amino acid to change
No amino acid change (silent mutation)
Suppose a mutation occurs in a portion of DNA and this alters the resulting mRNA that is transcribed. Examine the original and mutated mRNA sequences below and describe how the mutation impacts the resulting protein using either of the codon charts. You may check your work here.

mRNA from original DNA:


mRNA from mutated DNA:


It will cause the resulting amino acid to change
It will cause the protein synthesis to stop early
No amino acid change (silent mutation)
Identify the parts of the SARS-CoV-2 virus
Question 7
7.

Type the correct part of the virus, indicated by the number 7, in the space below.

Question 8
8.

Type the correct part of the virus, indicated by the number 8, in the space below.

Question 9
9.

Type the correct part of the virus, indicated by the number 9, in the space below.

Place the steps of infection in the correct order
Viruses travel to the surface of the human cell and are released outside the cell.
The proteins and RNA use the cell's membrane to form a new virus.
The virus uses protein spikes to bind to specific recepters on a human cell.
The human cell's ribosome will translate the viral RNA into proteins including RNA polymerase.
The viral RNA is transcriped into more copies that are then translated into more proteins and more complete strands of Viral RNA.
SARS-CoV-2 is brought into the body through the mouth or nose.
The RNA from the virus is released into the human cell.
Using your knowledge of mutations and the graph from the CDC, how would you classify the Delta variant based on current data:
Virus with a selective advantage
Virus with a selective disadvantage
Virus with a neutral mutation
How do DNA and mRNA vaccines produce spike proteins? Drag each item into the correct category.
Has an artificial membrane to allow it into the human cell
Completes the translation process to create spike proteins that mimic SARS-CoV-2 spike proteins
Is brought into a cell through an inactivated adenovirus
Completes transcription prior to translation
mRNA
DNA
Both
The way that genetic variation appears in a population is through:

1) Through new genetic combinations through meiosis
2) Errors occurring during the replication process
OR
3) Mutations caused by environmental factors.

Make a Claim: Based on what you have watched in the videos, as well as what we have learned in class, which type of mutation do you hypothesize led to the Delta variant of SARS-CoV-2?
New genetic combinations through meiosis
Errors occurring during the replication process
Mutations caused by environmental factors