2023-mcq-5
By j l
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Last updated about 2 years ago
111 Questions
• Directions: Each group of questions below concerns an experimental or laboratory situation or data. In each case, first study the description of the situation or data. Then choose the one best answer to each question following it.
Achondroplastic dwarfism is a dominant genetic trait that causes severe malformation of the skeleton. Homozygotes for this condition are spontaneously aborted (hence, the homozygous condition is lethal) but heterozygotes will develop to be dwarfed.
Matthew has a family history of the condition, although he does not express the trait. Jane is an achondroplastic dwarf.Matthew and Jane are planning a family of several children and want to know the chances of producing a child with
achondroplastic dwarfism.
Directions: Each group of questions below concerns an experimental or a laboratory situation. In each case, first study the description of the situation. Then choose the one best answer to each question following it.
In dogs, one pair of alleles determines coat color (dark and albino). Another pair of alleles determines hair length (short and long). Thus, each gamete will contain one of the coat-color alleles, C or c and one of the hair-length alleles, B or b. In repeated crosses of a specific dark, short-haired dog with an albino, long-haired dog, all the offspring were dark with short hair, as shown in cross I. However, in subsequent crosses of another dark, short-haired dog with a dark, long-haired dog, the ratios shown in cross II below were obtained.
Friedreich’s ataxia is an inherited disorder. Friedreich’s ataxia is caused by an insertion mutation in a noncoding portion of the FXN gene where a GAA
triplet is repeated hundreds of times. The FXN gene encodes the protein frataxin. A pedigree of a family with members affected by this disorder is shown in Figure 1.
A researcher collected DNA from several members of the family and used PCR to amplify the FXN genes from each individual’s DNA. The researcher then used DNA gel electrophoresis to separate the DNA. The results are shown in Figure 2.
The researcher also used a computer to model the structure of the mutant FXN allele. The model suggests that the repeated GAA triplets in the mutant FXN gene may lead to the formation of an unusual triple-stranded configuration of DNA (Figure 3).
Table I shows the results of breeding experiments to examine the inheritance of flower color (purple versus white) and pod shape (inflated versus constricted). For the crosses recorded in Table I, true-breeding parents were crossed to produce
F1 offspring, which were then testcrossed to homozygous recessive individuals. Table II shows the results of computer-simulated crosses to model the inheritance of leaf shape (broad versus narrow) and flower color (purple versus white).
Dystrophin is a protein that is expressed in certain muscle cells. In combination with other cellular proteins, dystrophin strengthens protein fibers in muscle cells to allow muscles to contract without injury.
Nucleotide deletions in the gene that encodes dystrophin are associated with the genetic disorder Duchenne Muscular Dystrophy (DMD). Individuals with DMDdo not produce functional dystrophin and, as a result, the protein fibers, andthen entire muscle cells, become damaged.
The history of DMD for three generations of a family is shown in Figure 1.
Individuals Ⅲ-1 and Ⅲ-2 plan to have children and wish to first determine whether individual Ⅲ-2 is a carrier of DMD. Individual Ⅲ-2 undergoes genetic testing to determine whether individual Ⅲ-2 carries a particular allele for themutated dystrophin that is associated with the disorder in this family. The results of gel electrophoresis analysis of the individual’s dystrophin alleles and the alleles of several family members are shown in Figure 2.
For following group of questions first study the description of the situation and diagram and then choose the one best answer to each question following it and fill in the corresponding oval on the answer sheet.
The pedigree of a family with a history of a particular genetic disease is shown below. Squares represent males and circles represent females. Shaded symbols represent those who have the disease.
• Directions: Each of the questions or incomplete statements below is followed by four suggested answers or completions. Select the one that is best in each case and then fill in the corresponding circle on the answer sheet.
The three-spined stickleback (Gasterosteus aculeatus) is a small fish found in both marine and freshwater environments.Marine stickleback populations consist mainly of individuals with armor-like plates covering most of their body surface (completely plated). Approximately 10,000 years ago, some marine sticklebacks colonized freshwater environments. After many generations in the freshwater environments, the freshwater stickleback populations lacked the armor plating
(low plated) typical of marine stickleback populations.
Over the period between 1957 and 2005, one freshwater population, in Lake Washington, a lake in a coastal region of the northwestern United States, changed from having a majority of individuals of the low-plated phenotype to having more individuals of the completely-plated phenotype than of the low-plated phenotype. Figure 1 shows the distribution of plated
phenotypes in Lake Washington sticklebacks at four time points between 1957 and 2005.
A single gene, ectodysplasin (EDA), is thought to be responsible for the variation in the number of armor plates in sticklebacks. Figure 2 shows a phylogenetic tree constructed by comparing DNA sequences of the EDA gene from a number of stickleback populations with low-plated or completely plated phenotypes. Figure 3 shows a phylogenetic tree constructed by comparing the sequences of 25 genes that were randomly selected from the same populations as shown in
Figure 2. In both figures, shaded populations display the completely plated phenotype.
Directions: This group of questions consists of five lettered headings followed by a list of phrases or sentences. For each phrase or sentence, select the one heading to which it is most closely related. Each heading may be used once, more than once, or not at all.
This group of questions refers to the probabilities below.
Assume that the alleles referred to all assort independently.
(A) 0
(B) 1/16
(C) 1/4
(D) 1/2
(E) 3/4
Tay-Sachs disease is a rare inherited disorder caused by an autosomal recessive allele of the HEXA gene. Affected individuals exhibit severe neurological symptoms and do not survive to reproductive age. Individuals who inherit one copy of the allele (Tay-Sachs carriers) typically show no symptoms of the disorder. The frequencies of Tay-Sachs carriers
in the general population of North America and in three different subpopulations are presented in the table.
• Directions: Each group of questions below concerns an experimental or laboratory situation or data. In each case, first study the description of the situation or data. Then choose the one best answer to each question following it.
A male fruit fly (Drosophila melanogaster) with red eyes and long wings was mated with a female with purple eyes and vestigial wings. All of the offspring in the F1 generation had red eyes and long wings. These F1 flies were test crossed with purple-eyed, vestigial-winged flies. Their offspring, the F2 generation, appeared as indicated below.
Protoporphyria is a genetic disorder characterized by an extreme sensitivity to sunlight. One form of protoporphyria is caused by a mutation in the ALAS2
gene that results in the accumulation of protoporphyrin, an organic compound, in the blood, liver, and skin. The pedigree in Figure 1 shows the incidence of protoporphyria in a particular family.
A student placed 20 tobacco seeds of the same species on moist paper towels in each of two petri dishes. Dish A was wrapped completely in an opaque cover to exclude all light. Dish B was not wrapped. The dishes were placed equidistant from a light source set to a cycle of 14 hours of light and 10 hours of dark. All other conditions were the same for both
dishes. The dishes were examined after 7 days, and the opaque cover was permanently removed from dish A. Both dishes were returned to the light and examined again at 14 days. The following data were obtained.
A student placed 20 tobacco seeds of the same species on moist paper towels in each of two petri dishes. Dish A was wrapped completely in an opaque cover to exclude all light. Dish B was not wrapped. The dishes were placed equidistant from a light source set to a cycle of 14 hours of light and 10 hours of dark. All other conditions were the same for both
dishes. The dishes were examined after 7 days and the opaque cover was permanently removed from dish A. Both dishes were returned to the light and examined again at 14 days. The following data were obtained.