A __________ is a segment of DNA that directs the development of some inherited traits.
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Question 8
8.
Gene expression regulates when and how often genes make proteins.
Make a claim: What can happen when gene expression does not work correctly?
Evidence: What data supports your claim?
Use the graphic below to help you with your answer:
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Genes produce _______
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Molly was born with vision impairment.
True
False
The gene therapy technique designed by Drs. Bennett and Maguire to cure Molly’s blindness involved using a virus as a vector to deliver the corrective gene into one of her eyes.
What necessary step must be taken before viruses are used in this way?
Doctors must first snip out the defective gene from a patient’s photoreceptor cells before using the virus to deliver the corrective gene.
Patients like Molly must first receive a vaccine for the virus so that they don’t get the disease that the virus carries.
The virus’s harmful genes and the ones the virus needs to replicate must be removed.
Patients must first take flu medicine to help them avoid any flulike symptoms that the virus causes.
Molly has a form of childhood blindness called Leber amaurosis. What caused her blindness?
early exposure to intense lights
mutations in a gene that is needed to maintain sight
a viral infection of the nervous system that attacked her optic nerves
an eye injury that occurred during birth
Recalling what you have learned in Bio A as well as the readings so far in this unit, what was the likely inheritance pattern in Molly's case?
Molly inherited 2 dominant alleles. One from each parent.
It is a sex-linked trait on the X chromosome.
Molly inherited 2 recessive alleles. One from each parent.
The mutations occurred after Molly's birth.
When Molly underwent treatment, the viruses that were injected into her retina each contained a copy of the RPE65 gene.
Why was this necessary for the treatment to be effective?
The RPE65 gene produces the RPE65 protein that Molly was missing to have normal vision.
The RPE65 gene is a carrier for the viral proteins.
The RPE65 gene is neccessary to stabilize the retna prior to further treatments.
The RPE65 gene in the virus attacks the removes the genes that were causing her blindness.