email me at teneal.metcalf@fwisd.org if you want to mention an error or potential improvement.
This is aligned to A Capella Science's "Evo-Devo" Despacito parody. I have as much rights to their production as they do to the original Despacito.
Content covered:
* Concepts of mitosis and differentiation, their role in development (distinguishes from meiosis/fertilization and binary fission)
* Evolution, natural selection, mutation, development
* Distinguishing between regulatory sequences and coding sequences
* Briefly reinforces monomers & polymers (focusing on nucleic acids and proteins)
* Briefly reinforces mRNA translated to protein/distinguishing from transcription.
* Briefly reinforces differences of prokaryotes, eukaryotes, and viruses
Designed to follow students having already learned about protein synthesis from gene to protein, brief introduction to gene switches as part of genetic medicine, and the basics of evolution. Designed to precede deeper concepts of gene regulation in eukaryotes and Hardy-Weinberg conditions for evolution.
You are not expected to get all of these right first go round, though many questions here rely on previous knowledge.
This is a mixture of lyrics prediction and assessment of your understanding of terms, and interpretation practice of a passage, to introduce a new topic. We will watch the video after, then receive a new copy of the lyrics to try again with the key turned on.

See...
One cell divide and decide on a thousand fates
Did you ever figure how they know?
The process of cell division as shown in this lyric is...

Now there's a science helping us to understand
How our cells encode this architectural plan
Signalling each other with genetic tools oh
Oh yeah
Wow
This process must happen in...
Match the images with the lyrics from this verse.
| Stavka koja se može prevući | arrow_right_alt | Odgovarajuća stavka |
|---|---|---|
| arrow_right_alt | Phenotype, the interface for mouse and man |
| arrow_right_alt | Genotype, the files and the subprograms |
| arrow_right_alt | What then, are the switches, circuit board, and boot code? |


In ___________ pathway
Changes tend to get torpedoed
Where they go calamity goes
As this cyclopic sheep knows...



Signals trigger patterns of complexity so
Switching up the switches of a signalling node
Gives a modular and simple way to evolve
Relate the terms, connecting thoughts from this verse.
| Stavka koja se može prevući | arrow_right_alt | Odgovarajuća stavka |
|---|---|---|
natural selection | arrow_right_alt | butterflies hatch with different genotypes |
regulatory sequence | arrow_right_alt | acts on the phenotype; brown butterfly survives and reproduces in brown land |
coding sequence | arrow_right_alt | the frequency of the brown phenotype becomes more common over generations |
evolution | arrow_right_alt | controls expression, ex. size, amount, and location of melanated spots on a butterfly's wing |
mutation | arrow_right_alt | is expressed (is transcribed to RNA and translated to protein), ex. melanin to make spots on a butterfly's wing |


Evo-Devo
This is how we go from single cells to people
Every generation and in life primeval
Life in variations endless and beautiful
Badaboom!
| Stavka koja se može prevući | arrow_right_alt | Odgovarajuća stavka |
|---|---|---|
a very long time ago | arrow_right_alt | from single cells to people |
evolution | arrow_right_alt | primeval |
development | arrow_right_alt | life in variations endless and beautiful |
| Stavka koja se može prevući | arrow_right_alt | Odgovarajuća stavka |
|---|---|---|
mitosis | arrow_right_alt | development |
mitosis followed by differentiation | arrow_right_alt | evolution |
mechanisms include mutation and natural selection | arrow_right_alt | sexual reproduction |
meiosis followed by fertilization | arrow_right_alt | asexual reproduction, repair |
If you're ever asked about morpholinos (unlikely, though similar concepts might show up), you won't need to know about them; they'll describe the morpholino as done above. You do need to know, though, that...

According to the lyrics, what does "Evo-Devo" primarily focus on?
What does the song imply about the relationship between evolution and development?
Which statement describes a common theme in the song?
Which are true messages supported by the lyrics?
I feel I learned something from this activity
I normally enjoy Biology
This assignment would have been better for me if...
Anything you would like your teacher to know? Include any suggested refinements.
I would like more assignments that are closely linked to music.
See
One cell divide and decide on a thousand fates
Did you ever figure how they know?
The concept of 'deciding on a thousand fates' is best described by the process of
Back before we blew up the Cambrian like a bomb bomb
Now my eye protein can make you see out of your bom bom
And Hedgehog and its relatives like Indian and Sonic
Identify the monomer and function of the underlined term.
From devo to evo
Parts have alter egos
Homologs evolved from repeats in the schema
Switch a couple bases in the proper places
You'll be watching flies grow legs out of their faces oh yeah
Select the appropriate polymer and function associated with the underlined term.