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Evo-Devo Despacito: Multi-Modal Connections & Lyrics Interactive (A Capella Science)

Last updated about 2 years ago

32 questions

Note from the author:

Deep Lyric Read Intro

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Video and Big Picture Questions

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email me at teneal.metcalf@fwisd.org if you want to mention an error or potential improvement.

This is aligned to A Capella Science's "Evo-Devo" Despacito parody. I have as much rights to their production as they do to the original Despacito.

Content covered:

* Concepts of mitosis and differentiation, their role in development (distinguishes from meiosis/fertilization and binary fission)
* Evolution, natural selection, mutation, development
* Distinguishing between regulatory sequences and coding sequences

* Briefly reinforces monomers & polymers (focusing on nucleic acids and proteins)
* Briefly reinforces mRNA translated to protein/distinguishing from transcription.
* Briefly reinforces differences of prokaryotes, eukaryotes, and viruses

Designed to follow students having already learned about protein synthesis from gene to protein, brief introduction to gene switches as part of genetic medicine, and the basics of evolution. Designed to precede deeper concepts of gene regulation in eukaryotes and Hardy-Weinberg conditions for evolution.

Question 1

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Question 4

4.

Choose an appropriate term for this blank in the lyric. Don't stress about whether it's perfect or not.

Did you ever figure how they know?

We
Are built of modules combined in a planned-out way
Each new _______ must be told where to go
Oh

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Question 6

6.

Draggable item		Corresponding Item

1.5

Question 7

7.

Evo-Devo
Looking at the logic in the ways that we grow

Every __________directed by a signal key code

__________ that can activate, enhance or veto*

Evo-Devo

In this verse, the term veto could be replaced without losing meaning... __________

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Question 9

9.

Signal mapping tells each region what it ought to be yo
With circuits so deeply built upon
They're __________than the Paleo
The Paleozoic Era baby

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Question 12

12.

See down they cascade like a _______ 
Like you and I drosophila
The path that makes us optical
Was laid a long long time ago

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Question 15

15.

Adult and embryo
Mostly don't evolve in the genes of the (whole) __________
Safer the mutation aimed at regulation
Keep the building blocks and swap their activation

The word that could best replace building blocks in the above verse is... __________

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2.5

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Question 18

18.

Look at how our spinal segments generate a neat row

Built on a molecular clock
One cycle, one vertebra
One vertebra one vertebra baby

__________ its rate is snakes' developmental cheat code

That and where a lizard's feet grow
They turn off distal aminos

The best synonym for the underlined text is __________.

1

1

2

Question 22

22.

From devo to evo
Larva to mosquito
Patterns are resolved as the signals proceed yo
Map out a gene with a glow tag
Kill it with a morpholino
Short oligo morpholino baby

From devo to evo
Voyage of the Beagle
Body plans evolve when proteins steer the genome
In this manner life's beauty grows
Aesthetica in vivo
Evo-Devo

If you're asked about morpholinos on the test, they'll give you extra information. What a morpholine usually does is block __________ of mRNA into protein.

Question 23

23.

If you're ever asked about morpholinos (unlikely, though similar concepts might show up), you won't need to know about them; they'll describe the morpholino as done above. You do need to know, though, that...

Other Answer Choices:

RNA

DNA

Question 24

24.

Question 25

25.

Question 26

26.

Question 27

27.

Question 28

28.

Question 29

29.

Question 30

30.

Question 31

31.

Anything you would like your teacher to know? Include any suggested refinements.

Question 32

32.

You are not expected to get all of these right first go round, though many questions here rely on previous knowledge. 

This is a mixture of lyrics prediction and assessment of your understanding of terms, and interpretation practice of a passage, to introduce a new topic. We will watch the video after, then receive a new copy of the lyrics to try again with the key turned on.

I am predicting lyrics; we will watch the video after. Better to make mistakes in my genuine learning experience than use a resource. Working with the class!

I am predicting lyrics; I will watch the video after. I should Google the questions so I know I have the right answers . I am working on my own at my own pace because I missed class.

I am predicting lyrics; I will watch the video after. Better to make mistakes in my genuine learning experience than use a resource. Working on my own at my own pace because I missed class.

I am predicting lyrics; we will watch the video after. I should Google the questions so I know I have the right answers. Working with the class!

Question 2

2.

Question 3

3.

Question 5

5.

Match the images with the lyrics from this verse.

Phenotype, the interface for mouse and man

Genotype, the files and the subprograms

What then, are the switches, circuit board, and boot code?

Question 8

8.

Signals are controlled by other __________that signal
Calculating in a network labyrinthal
Where the heart and liver and the hands and feet go

Question 10

10.

Question 11

11.

The word changes in the above verse refers to _______ in the genome.

Question 13

13.

Question 14

14.

Set up set up 
In a _______ (this  is shown in the image; we've seen it before as a concentration __________ from high to low... if you can't come up with it, you'll see it soon!)


On segments embryonic
Split forebrains and asymmetric parts depend upon it
Flipping on genetic switches and logic
From devo to evo

Question 16

16.

Question 17

17.

Draggable item		Corresponding Item

Question 19

19.

They in the above verse refers to the _______ .

Question 20

20.

Draggable item		Corresponding Item

Question 21

21.

Draggable item		Corresponding Item

According to the lyrics, what does "Evo-Devo" primarily focus on?

Evolution and signals 

Protein activation

Cell division 

Development and evolution

Evolution and devolution

What does the song imply about the relationship between evolution and development?

Studying one field provides insights for the other

They contradict each other, highlighting flaws in the theory of evolution

They must be studied separately because they have little in common

Which statement describes a common theme in the song?

Switching genes alters biological traits

Signalling nodes are obsolete

Genetic mutations are always harmful 

Protein activation hinders growth

Which are true messages supported by the lyrics?

Cells evolve randomly.

Evolution follows a specific logic.

Development is an unpredictable process.

Genetic mutations are reversible.

Mutations in regulatory sequences are most responsible for the evolution of different species.

Mutations in coding sequences are most responsible for the evolution of different species.

I feel I learned something from this activity

Strongly agree

Agree

Disagree

Strongly Disagree

I normally enjoy Biology

Strongly agree 

Agree

Neutral

Disagree

Strongly disagree

This assignment would have been better for me if...

I would have liked to watch the song first WITHOUT having viewed the questions, then answer the questions WITHOUT rewatching the song

I was content with attempting the questions BEFORE watching the song, AND THEN re-answering the lyrics as we did in class

I would have liked having viewed the questions but NOT answering them, then watching the song, then answering the questions WITHOUT rewatching the song

other

I would like more assignments that are closely linked to music.

Strongly agree

Agree

Disagree

Strongly disagree 

Neutral

See...
One cell divide and decide on a thousand fates
Did you ever figure how they know?

The process of cell division as shown in this lyric is...

mitosis

meiosis

binary fission

See
One cell divide and decide on a thousand fates
Did you ever figure how they know?

The concept of 'deciding on a thousand fates' is best described by the process of

meiosis

mitosis

evolution

natural selection

mutation

differentiation

Now there's a science helping us to understand

How our cells encode this architectural plan
Signalling each other with genetic tools oh

Oh yeah

Wow

This process must happen in...

eukaryotes

viruses

prokaryotes

In ___________ pathway 
Changes tend to get torpedoed
Where they go calamity goes
As this cyclopic sheep knows...

every single

a crucial

a non-essential

Back before we blew up the Cambrian like a bomb bomb
Now my eye protein can make you see out of your bom bom
And Hedgehog and its relatives like Indian and Sonic

Identify the monomer and function of the underlined term.

nucleotides

encode information

do work

amino acids

fatty acids

provide energy

monosaccharides

most of cell membrane structure, insulation

From devo to evo
Parts have alter egos
Homologs evolved from repeats in the schema
Switch a couple bases in the proper places
You'll be watching flies grow legs out of their faces oh yeah

Select the appropriate polymer and function associated with the underlined term.

compose most of cell membranes, insulation

do work

provide energy

nucleic acid

lipid

carbohydrate

encode information

protein

Signals trigger patterns of complexity so
Switching up the switches of a signalling node 
Gives a modular and simple way to evolve

Relate the terms, connecting thoughts from this verse.

natural selection

butterflies hatch with different genotypes

regulatory sequence

acts on the phenotype; brown butterfly survives and reproduces in brown land

coding sequence

the frequency of the brown phenotype becomes more common over generations

evolution

controls expression, ex. size, amount, and location of melanated spots on a butterfly's wing

mutation

is expressed (is transcribed to RNA and translated to protein), ex. melanin to make spots on a butterfly's wing

Evo-Devo

This is how we go from single cells to people
Every generation and in life primeval
Life in variations endless and beautiful
Badaboom!

a very long time ago

from single cells to people

evolution

primeval

development

life in variations endless and beautiful

mitosis

development

mitosis followed by differentiation

evolution

mechanisms include mutation and natural selection

sexual reproduction

meiosis followed by fertilization

asexual reproduction, repair