This activity has students study a visual of a population in Hardy-Weinberg equilibrium, apply allele and genotype terminology, the variables of Hardy-Weinberg, and walks them through calculating Hardy-Weinberg.
Includes a visual pie-chart calculator: students can input p and q values and see the genotype and phenotype frequencies for the population.
Numerous hints included. Paul Andersen's video on HWE is referenced.
This is intended to follow students work with understanding the formula (see "Understanding Hardy-Weinberg Formula".)
This is designed to be independent practice completed alongside a series of Pear Practice activities that are whole-class. Before beginning, students should have been introduced to the Hardy-Weinberg formula. I do so in my classroom by introducing the underlying concepts before they ever see the math.
The problems on the Practice Calculation page come from Tiffany Jones' formative, also available in the public library.
The Visualization app is made through Excel. You may download and host your own copy if you would like to make minor changes.
For support or suggested edits, message teneal.metcalf@fwisd.org

Purple is dominant to white in this population of flowers. Label accordingly.

The video is optional but walks you through the way to solve problems directly. Alternatively, you can attempt the problems using the information below- there are numerous hints in the first set!
I am watching the optional video
Optional space for upload of physical notes or typed notes
The Hardy-Weinberg Theorem basically states that if no evolution is occurring, then the allele frequencies will remain in equilibrium in each succeeding generation of sexually reproducing individuals. In order for equilibrium to remain in effect (i.e. that no evolution is occurring), then the following five conditions must be met:
No mutations must occur so that new alleles do not enter the population.
No gene flow can occur (i.e. no migration of individuals into, or out of, the population).
Random mating must occur (i.e. individuals must pair by chance)
The population must be large so that no genetic drift (random chance) can cause the allele frequencies to change.
No selection can occur so that certain alleles are not selected for, or against.
We can use the Hardy-Weinberg equation to estimate the frequency of alleles and genotypes in a population. According to this equation:
p = the frequency of the dominant allele
q = the frequency of the recessive allele
For a population in genetic equilibrium:
And, So,
p + q = 1.0 (The sum of the frequencies of both alleles is 100%.) (p + q)2 = 1
p2 + 2pq + q2 = 1
The three terms of this binomial expansion indicate the frequencies of the three genotypes:
p2 = frequency of AA (homozygous dominant)
2pq = frequency of Aa (heterozygous)
q2 = frequency of aa (homozygous recessive)
Notice that allele frequencies are represented by p and by q, whereas genotype frequencies of individuals are represented by p2, 2pq and q2.
Answer the following questions using the Hardy-Weinberg equation. Be sure to express the relative frequencies as decimals (i.e., 0.16) and percentages as percentages (i.e., 16%)
**NOTE: The system has the "correct" answers denoted by the above format**

The frequency of recessive allele:
The frequency of the dominant allele:
The percentage of the “Bb” genotype:

The frequency of the recessive allele:
The frequency of the dominant allele:

The frequency of the dominant allele:
The frequency of the recessive allele:
The percentage of mice that are homozygous dominant:
The percentage of mice that are heterozygous:

The frequency of the dominant allele:
The frequency of the recessive allele:
The percentage of the population that is homozygous dominant:
The percentage of the population that is heterozygous:

The frequency of the dominant allele:
The frequency of the recessive allele:
The percentage of the population that is homozygous dominant:
The percentage of the population that is heterozygous
You must be able to perform HWE calculations without this app; Use the visual calculator to check your work and help you 'see' what the variables you have just completed represent.
Check the resources you will have available to you during the AP Exam.
You have sampled a population in which you know that the percentage of the homozygous recessive genotype (aa) is 36%.
The frequency of the “a” allele:
The frequency of the “A” allele:
The frequency of the “aa” genotype, to the second decimal place:
The frequency of the “AA” genotype:
The frequency of the “Aa” genotype:
Set up the calculator at left with the p & q values you found, then check that the genotype frequencies match what you calculated.
The HWE calculator will not be available on the test, but visualizing this way may help you process the math.
Screenshot the allele, genotype, and phenotype frequencies pie charts and upload them here. You are welcome to use this calculator again to check your work and visualize what is happening as you solve the problems on the next page.
The percentage of mice that are homozygous recessive
The percentage of the population that is homozygous recessive:
The percentage of the population that is homozygous recessive