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Sickle Cell Trait & Malaria - Review of Natural Selection

Last updated over 1 year ago
21 questions
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1

Malaria is caused by
This images shows a single malaria parasite about to enter a human red blood cell

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3

Describe the effect malaria has had on the human species over our history?

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3

Describe how the parasite enters the body and spreads to cause malarial disease

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3

Match the genotypes with the phenotypes (Hb refers to hemoglobin, A is the normal allele, S is the sickle cell mutation allele

Draggable itemCorresponding Item
HbA/HbS
normal hemoglobin/no malarial protection
HbS/HbS
sickle cell trait (50% of hemoglobin has mutation) - no sickle cells diease & protection against malaria
HbA/HbA
sickle cell disease
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6

Put the steps of natural selection in order

  1. Competition
  2. Differential Reproduction
  3. Overproduction - too many offspring
  4. Variation
  5. Differential Survival
  6. Speciation - creation of a new species
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5
Draggable itemCorresponding Item
Differential Reproduction
a population has a mix of people with 3 genotypes; HbA/HbA, HbA/HbS, HbS/HbS
Variation
Parents have offspring with the 3 possible genotypes in an area that has high malaria infection rates
Differential Survival
People with sickle cell trait (HbA/HbS) have protection against malaria while people who are HbA/HbA have no protection
Too many offspring - overproduction
People who have sickle cell trait are more likely to survive in areas with high rates of malaria
Competition
People who have sickle cell trait are more likely to survive in areas with high rates of malaria, therefore are able to reproduce
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3
Drag the correct percentages for the frequency of the sickle cell trait to the 3 areas on the map (go from left to right on the map)
Other Answer Choices:
< 1% of the population (less than 1 person out of 100 people have sickle cell trait)
> 20% of the population (20 people out of 100 total people have sickle cell trait
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1

Why do the dark purple areas of the map have so many more people with sickle cell trait than the area of light purple?

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1
Drag and drop the correct labels onto the map - start with the first box and go across the map from left to right. You can reused the answers!
Other Answer Choices:
area where sickle cell trait would be strongly selected for
area where sickle cell trait would be selected against by natural selection
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3
This images shows a sample of red blood cells of a HbA/HbA person on the left and a HbA/HbS person on the right. The person on the left has __________ malarial parasites in their red blood cells compared to the person on the right. This is because having __________ makes it more difficult for the parasite to live inside the red blood cells. Therefore sickle cell trait __________ a malarial infection
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2
Drag and drop the correct labels to each side of the diagram
Other Answer Choices:
Area with low malaria
Area with high malaria
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2

Select all the statements that supported by the diagram

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1

2 parents that are both heterozygotes for the sickle cell allele (have sickle cell trait)... what would their genotypes be?

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1

Draw a punnett square and fill out the boxes for the above cross

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1
From the above punnett square, what % of children do not have sickle cell anemia AND have no protection vs. malaria? ______________ ______ What % of children do not have sickle cell anemia AND have protection vs. malaria? ______________ _____
What % of children have sickle cell anemia? _____________ _______ (You can reuse the answers!)
Other Answer Choices:
25%
50%
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1
On an isolated island in the middle of the Pacific ocean, a group of 50 couples started a new population. Every member of the population was a carrier for sickle cell anemia (sickle cell trait - HbA/HbS). When each couple had children, the cross was HbA/HbS x HbA/HbS. The 50 couples had a total of 224 children - 66 HbA/HbA, 125 HbA/HbS and 33 HbS/HbS. Unfortunately the couple unintentionally brought a breeding population of malaria-carrying mosquitos with them. The mosquitos reproduced and grew their population. Within a few years, the island was full of malaria-carrying mosquitos. Use the dropdowns provided to make predictions as to what would happen to each of the three genotypes as their descendents lived on the island over the next 250 years.

The HbA/HbA genotype (started at 66 of 224) will __________. The HbA/HbS (sickle cell trait - originally was 125 out of 224) will __________. The HbS/HbS genotype (sickle cell anemia) will __________
1

How would you describe the cause of the change in population of humans on the island over the next 250 years?

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3

Write 3 take-aways from above video

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3

From the edpuzzle video, explain how this potential treatment for sickle cell anemia would work.

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3

Summarize what the latest is with this treatment for sickle cell anemia

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3

Summarize the breakthrough described in the video and what is means for people who suffer from sickle cell anemia