Mutations 2026

Last updated about 1 month ago

15 questions

Mutations 2026

Last updated about 1 month ago

15 questions

Draggable item		Corresponding Item
What bases will you find in DNA		A, T , C , G
What bases will you find in RNA		A, U , C , G
How many stands are in DNA		2
How many stands are in RNA		1

Which base would match with G in DNA

Which base would match with A in DNA

If I had a gene (a section of DNA) with the bases A T C G A C T G A, what would the matching RNA strand be?

Section 2 

Iii. Analyze information on the impact of three different mutations within DNA.
EXT: iii. Evaluate the relative consequences of these types of mutations

You will be presented with three mutations
.
Your task is to work in pairs to:
1. Analyse what type of mutation occurred using the steps on slide 12.
2. Evaluate which one of the mutations you and your partner think is more catastrophic. (Extension)

Resources to help
a. Class slides
b. The genetic codon chart  below. You could also use the codon wheel.
c. Summary on the types of mutations

MUTATION 1:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 2:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 3:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

Which mutation 1, 2 or 3 do you think is the most catastrophic?

EXTENSION ACTIVITY 

Watch this video on sickle cell anemia.

Sickle Cell Anemia
Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the hemoglobin molecule.  Hemoglobin carries oxygen in your red bloods cells.  The mutation causes these red blood cells to become stiff & sickle-shaped when they release their oxygen.  The sickled cells tend to get stuck in blood vessels, causing pain and increased risk of stroke, blindness, damage to the heart & lungs, and other conditions.
--- Analyze the DNA strands below to determine what amino acid is changed AND what type of mutation occurred 📷
Normal hemoglobin DNA  C A C  G T A  G A C  T G A  G G A  C T C …

Transcribe the normal hemoglobin mRNA.

Translate the mRNA to the normal sequence of amino acids.

Transcribe the following DNA for the hemoglobin in sickle cell anemia patients in to the corresponding mutated mRNA:

Sickle cell hemoglobin DNA C A C G T A G A C T G A G G A C A C …

What changed? Identify which type of point mutation occurred (i.e. substitution, deletion, insertion) and where.

Translate the mutated mRNA into the mutated sequence of amino acids.

What changed? Is the amino acid sequence the same? If not, which amino acids were changed and what type of change has occurred (i.e. silent, missense, nonsense, frameshift)?

Mutations 2026

Mutations 2026

Which base would match with G in DNA

Which base would match with A in DNA

If I had a gene (a section of DNA) with the bases A T C G A C T G A, what would the matching RNA strand be?

MUTATION 1:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 2:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 3:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

Which mutation 1, 2 or 3 do you think is the most catastrophic?

Transcribe the normal hemoglobin mRNA.

Translate the mRNA to the normal sequence of amino acids.

Transcribe the following DNA for the hemoglobin in sickle cell anemia patients in to the corresponding mutated mRNA:

Sickle cell hemoglobin DNA C A C G T A G A C T G A G G A C A C …

What changed? Identify which type of point mutation occurred (i.e. substitution, deletion, insertion) and where.

Translate the mutated mRNA into the mutated sequence of amino acids.

What changed? Is the amino acid sequence the same? If not, which amino acids were changed and what type of change has occurred (i.e. silent, missense, nonsense, frameshift)?

Using your knowledge of the video and sickle cell anemia, explain what effect this change will have on the hemoglobin protein.

Which base would match with G in DNA

Which base would match with A in DNA

If I had a gene (a section of DNA) with the bases A T C G A C T G A, what would the matching RNA strand be?

MUTATION 1:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 2:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 3:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

Which mutation 1, 2 or 3 do you think is the most catastrophic?

Transcribe the normal hemoglobin mRNA.

Translate the mRNA to the normal sequence of amino acids.

Transcribe the following DNA for the hemoglobin in sickle cell anemia patients in to the corresponding mutated mRNA:

Sickle cell hemoglobin DNA C A C G T A G A C T G A G G A C A C …

What changed? Identify which type of point mutation occurred (i.e. substitution, deletion, insertion) and where.

Translate the mutated mRNA into the mutated sequence of amino acids.

What changed? Is the amino acid sequence the same? If not, which amino acids were changed and what type of change has occurred (i.e. silent, missense, nonsense, frameshift)?

Using your knowledge of the video and sickle cell anemia, explain what effect this change will have on the hemoglobin protein.

Mutations 2026

Mutations 2026

Which base would match with G in DNA

Which base would match with A in DNA

If I had a gene (a section of DNA) with the bases A T C G A C T G A, what would the matching RNA strand be?

MUTATION 1: a. Write out the original RNA & amino acidsb. Write out the mutated RNA & amino acidsc. Write out what type of mutation has occurred(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 2: a. Write out the original RNA & amino acidsb. Write out the mutated RNA & amino acidsc. Write out what type of mutation has occurred(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 3: a. Write out the original RNA & amino acidsb. Write out the mutated RNA & amino acidsc. Write out what type of mutation has occurred(EXT: Circle the change and state if there will be effects in the person or not)

Which mutation 1, 2 or 3 do you think is the most catastrophic?

Transcribe the normal hemoglobin mRNA.

Translate the mRNA to the normal sequence of amino acids.

Transcribe the following DNA for the hemoglobin in sickle cell anemia patients in to the corresponding mutated mRNA:Sickle cell hemoglobin DNA C A C G T A G A C T G A G G A C A C …

What changed? Identify which type of point mutation occurred (i.e. substitution, deletion, insertion) and where.

Translate the mutated mRNA into the mutated sequence of amino acids.

What changed? Is the amino acid sequence the same? If not, which amino acids were changed and what type of change has occurred (i.e. silent, missense, nonsense, frameshift)?

Using your knowledge of the video and sickle cell anemia, explain what effect this change will have on the hemoglobin protein.

Which base would match with G in DNA

Which base would match with A in DNA

If I had a gene (a section of DNA) with the bases A T C G A C T G A, what would the matching RNA strand be?

MUTATION 1: a. Write out the original RNA & amino acidsb. Write out the mutated RNA & amino acidsc. Write out what type of mutation has occurred(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 2: a. Write out the original RNA & amino acidsb. Write out the mutated RNA & amino acidsc. Write out what type of mutation has occurred(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 3: a. Write out the original RNA & amino acidsb. Write out the mutated RNA & amino acidsc. Write out what type of mutation has occurred(EXT: Circle the change and state if there will be effects in the person or not)

Which mutation 1, 2 or 3 do you think is the most catastrophic?

Transcribe the normal hemoglobin mRNA.

Translate the mRNA to the normal sequence of amino acids.

Transcribe the following DNA for the hemoglobin in sickle cell anemia patients in to the corresponding mutated mRNA:Sickle cell hemoglobin DNA C A C G T A G A C T G A G G A C A C …

What changed? Identify which type of point mutation occurred (i.e. substitution, deletion, insertion) and where.

Translate the mutated mRNA into the mutated sequence of amino acids.

What changed? Is the amino acid sequence the same? If not, which amino acids were changed and what type of change has occurred (i.e. silent, missense, nonsense, frameshift)?

Using your knowledge of the video and sickle cell anemia, explain what effect this change will have on the hemoglobin protein.

MUTATION 1:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 2:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 3:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

Transcribe the following DNA for the hemoglobin in sickle cell anemia patients in to the corresponding mutated mRNA:

Sickle cell hemoglobin DNA C A C G T A G A C T G A G G A C A C …

MUTATION 1:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 2:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

MUTATION 3:

a. Write out the original RNA & amino acids
b. Write out the mutated RNA & amino acids
c. Write out what type of mutation has occurred
(EXT: Circle the change and state if there will be effects in the person or not)

Transcribe the following DNA for the hemoglobin in sickle cell anemia patients in to the corresponding mutated mRNA:

Sickle cell hemoglobin DNA C A C G T A G A C T G A G G A C A C …