Sickle-shaped red blood cells result from a mutation in the gene that codes or hemoglobin. This mutation results in sickle-cell anemia. A partial sequence of bases from a normal hemoglobin gene and a sequence that results in sickle-cell anemia are shown below.

What type of mutation is depicted in this sequence?

If the code on the original strand of DNA was TGAT, and a mutation occurred which caused the new code to read TCGAT..

Original DNA: TGAT

Mutated DNA: TCGAT

This type of mutation is called a(n) __________________.

Use the RNA Codon Chart to identify the effects of the mutation below.

Original: T A C A C T G A G G A C A C G T G A

Mutated: A U U G A C U C C U G U G C A C U

Which of these is the direct result of an error in the transcription of a DNA nucleotide?

Do all changes to the original DNA result in a mutated protein?

Observe the mutations in the diagram below.

Which mutations would cause a frameshift? Select TWO mutations.

A certain mutation in the gene for hemoglobin results in the red blood cells becoming sticky, rigid, and irregularly shaped. These irregularly shaped red blood cells block the flow of blood throughout the body. A single base mutation is responsible for these irregularly shaped blood cells.

Which of these mutations most likely results in the mutated hemoglobin gene?

The table below shows a DNA sequence and three types of mutations that can change the DNA sequence.

Which mutation will cause translation to STOP?

In the 1960's, the molecular biologist George Streisinger developed the "Strand-Slippage Hypothesis". Streisinger noticed that mutations occurred in areas of DNA that contained many repeated sequences. When a strand-slippage error occurs, an insertion mutation can result.

How does the insertion mutation affect the DNA?

The reason why there was no change in the hemoglobin protein is because…